Topic: Glymphatic System in Alzheimer's Disease.
Speaker 1 : Hongsheng Xie, Ph.D. Candidate
Date: 13/05/2024, 14:00
Location: The lab of HMRRC (10011, the 8th Teaching Building)
Speaker 1: Hongsheng Xie, Ph.D. Candidate
Keypoints：
Questions: What is the role of glymphatic markers in the association between cerebral small vessel disease and Aβ in Alzheimer's Disease continuum?
Meaning: This study provided evidence that AD pathology (Aβ) and CSVD were associated with glymphatic dysfunction, which is further related to cognitive impairment.
Speaker 2: Ruoqiu Gan, M.Med. Candidate
Title: Magnetic Resonance Images Implicate That Glymphatic Alterations Mediate Cognitive Dysfunction in Alzheimer Disease.
Keypoints：
Questions: What is the associations between glymphatic activity and amyloid and tau deposition and cognitive dysfunction in patients with AD?
Findings:
(1) ALPS-index associated with amyloid and tau deposition GMV ratios and cognition.
(2) ALPS-index as a significant mediator between deposition of amyloid and tau proteins, cognitive dysfunction, and GMV ratios.
(3) ALPS-index as a significant mediator in cognitive dysfunction after correction for GMV ratios.
Meaning: This study indicates that ALPS-index acts as a significant mediator in the relationship between the burden of amyloid and tau proteins and cognitive dysfunction.
